天然产物抗血管生成的研究进展

J4 ›› 2010, Vol. 23 ›› Issue (6): 34-38.

天然产物抗血管生成的研究进展

陈锡强, 侯海荣, 刘可春, 王希敏, 王思锋, 何秋霞

山东省科学院生物研究所，山东省生物传感器重点实验室，山东济南 250014

收稿日期:2010-07-13 出版日期:2010-12-20 发布日期:2010-12-20
基金资助:
山东省科学院博士基金资助项目(SY2007BS10)

Research Advances of Natural Products Antiangiogenesis

CHEN Xi-Qiang, HOU Hai-Rong, LIU Ke-Chun, WANG Xi-Min, WANG Si-Feng, HE Qiu-Xia

Shandong Provincial Key Laboratory of Biosensors,Biology Institute of Shandong Academy of Sciences, Jinan 250014, China

Received:2010-07-13 Online:2010-12-20 Published:2010-12-20

摘要/Abstract

摘要：

抗血管生成治疗已成为恶性肿瘤治疗的重要途径。本文对近年来抗肿瘤血管生成的天然产物研究进行了归类，已有研究发现萜类、酚类、黄酮类、生物碱类和蒽醌类等天然产物有抑制血管生成的作用，并且通过细胞与分子学实验揭示了其抑制血管生成的机理。本文综述了近年天然产物抑制肿瘤血管生成的研究成果，希望能为中药材抗肿瘤药物开发提供新思路。

关键词: 天然产物, 血管生成

Abstract:

Anti-angiogenesis therapy has become an important anti-cancer approach. This paper classifies such recently reported natural products of antitumor neovascularization as terpenoids, phenols, flavonoids, alkaloids, anthraquinones, etc. This paper also surveys some fruits on tumor angiogenesis suppression of natural products in order to provide some new ideas for the development of Chinese antitumor drugs.

Key words: natural products, angiogenesis

中图分类号:

R285.5

陈锡强, 侯海荣, 刘可春, 王希敏, 王思锋, 何秋霞. 天然产物抗血管生成的研究进展[J]. J4, 2010, 23(6): 34-38.

CHEN Xi-Qiang, HOU Hai-Rong, LIU Ke-Chun, WANG Xi-Min, WANG Si-Feng, HE Qiu-Xia. Research Advances of Natural Products Antiangiogenesis[J]. J4, 2010, 23(6): 34-38.