头孢硫脒热分解动力学研究

doi:10.3976/j.issn.1002-4026.2019.06.006

山东科学 ›› 2019, Vol. 32 ›› Issue (6): 34-42.doi: 10.3976/j.issn.1002-4026.2019.06.006

头孢硫脒热分解动力学研究

于帅，程燕，薛富民^*

齐鲁工业大学（山东省科学院）山东省分析测试中心，山东济南 250014

收稿日期:2019-07-18 出版日期:2019-12-20 发布日期:2019-12-11
通信作者: 薛富民，男，副研究员，研究方向为纳米材料、药物载体等。E-mail: xuefei_008@163.com
作者简介:于帅（1989—），男，博士，研究方向为药物结晶过程控制。E-mail: yushuaiyoyo@126.com
基金资助:
国家自然科学基金（91434126, 61633006, 21703126）；山东省重点研发计划（2018GSF117006，2019GSF109063）

Kinetics of the thermal decomposition of cefathiamidine

YU Shuai, CHENG Yan, XUE Fu-min^*

Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Science), Jinan 250014, China

Received:2019-07-18 Online:2019-12-20 Published:2019-12-11

摘要/Abstract

摘要： 采用TG-DTG(thermal gravity -differential thermal gravity)法研究了头孢硫脒的热分解过程动力学。头孢硫脒热分解为一步完成，开始失重时的温度为430~450 K。运用Flynn-Wall-Ozawa法、Kissinger-Akahira-Sunose法和Starink法计算了头孢硫脒热分解过程中的活化能值，发现活化能均随着热分解转化率的升高而降低。通过Málek 法得到头孢硫脒晶体的热分解动力学三因子分别为E_α=109 kJ/mol、ln A=30.60 s^-1、最概然动力学模型为SB(0.241 7, 0.658 9)。预测头孢硫脒在273.15 K以下时的理论贮存期为3年。

关键词: 头孢硫脒, 热分解, 热分析动力学, TG-DTG, 贮存期

Abstract: The kinetics of the thermal decomposition of cefathiamidine was investigated by thermal gravity-differential thermal gravity (TG-DTG). The thermal decomposition of cefathiamidine was accomplished in one step, and the initial decomposition temperature ranged from 430 K to 450 K. The activation energy of the thermal decomposition process of cefathiamidine was obtained using the Flynn-Wall-Ozawa method, Kissinger-Akahira-Sunose method, and Starink method. The activation energy decreased with an increase in the thermal decomposition conversion rate. Further, the three factors of the thermal decomposition kinetics of the ceftiamidine crystals were obtained using the Málek method. The calculated E_αwas 109 kJ/mol, lnA was 30.60 s^-1, and most probable kinetic model was SB(0.241 7, 0.658 9). The calculated theoretical shelf time of cefathiamidine was three years below 273.15 K.

Key words: cefathiamidine, thermal decomposition, kinetics of thermal analysis, TG-DTG, shelf time

中图分类号:

R912

于帅, 程燕, 薛富民. 头孢硫脒热分解动力学研究[J]. 山东科学, 2019, 32(6): 34-42.

YU Shuai, CHENG Yan, XUE Fu-min. Kinetics of the thermal decomposition of cefathiamidine[J]. Shandong Science, 2019, 32(6): 34-42.

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头孢硫脒热分解动力学研究

Kinetics of the thermal decomposition of cefathiamidine

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