SHANDONG SCIENCE ›› 2018, Vol. 31 ›› Issue (3): 113-118.doi: 10.3976/j.issn.1002-4026.2018.03.018

• Other Research Article • Previous Articles     Next Articles

Spectroscopic characteristics and structural identification of cefamandole nafate

LIN Yun-liang, GAO Hong-mei, LI Feng, WEI Xiang-yu,WANG Zhi-wei, JIANG Hai-long, WANG Dai-jie   

  1. Shandong Analysis and Test Center, Qilu University of Technology(Shandong Academy of Sciences),Jinan 250014,China
  • Received:2017-09-08 Online:2018-06-20 Published:2018-06-20

Abstract:

A method was established for the chemical structure determination of cefamandole nafate by analytical instruments. The elemental analyzer was used to analyze the elemental composition of cefamandole nafate, and nuclear magnetic resonance, mass spectrometry, infrared spectrometry and ultraviolet spectrometry were adopted to analyze the chemical structure of cefamandole nafate. The chemical structure of cefamandole nafate was confirmed to be sodium 7-D-[(2-hydroxy-2phenylacetyl)amino]3-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate. This method is accurate and practical, which can provide a comprehensive reference for the structural identification of cefamandole nafate.

Key words: structural identification, spectroscopic characteristics, spectroscopy, cefamandole nafate

CLC Number: 

  • R927